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Inhibition of ABCB1 and ABCG2 at the Mouse Blood-Brain Barrier with Marketed Drugs To Improve Brain Delivery of the Model ABCB1/ABCG2 Substrate [11C]erlotinib.
Traxl, Alexander; Mairinger, Severin; Filip, Thomas; Sauberer, Michael; Stanek, Johann; Poschner, Stefan; Jäger, Walter; Zoufal, Viktoria; Novarino, Gaia; Tournier, Nicolas; Bauer, Martin; Wanek, Thomas; Langer, Oliver.
Affiliation
  • Traxl A; Center for Health & Bioresources , AIT Austrian Institute of Technology GmbH , 2444 Seibersdorf , Austria.
  • Mairinger S; Center for Health & Bioresources , AIT Austrian Institute of Technology GmbH , 2444 Seibersdorf , Austria.
  • Filip T; Center for Health & Bioresources , AIT Austrian Institute of Technology GmbH , 2444 Seibersdorf , Austria.
  • Sauberer M; Center for Health & Bioresources , AIT Austrian Institute of Technology GmbH , 2444 Seibersdorf , Austria.
  • Stanek J; Center for Health & Bioresources , AIT Austrian Institute of Technology GmbH , 2444 Seibersdorf , Austria.
  • Poschner S; Department of Clinical Pharmacy and Diagnostics , University of Vienna , 1090 Vienna , Austria.
  • Jäger W; Department of Clinical Pharmacy and Diagnostics , University of Vienna , 1090 Vienna , Austria.
  • Zoufal V; Center for Health & Bioresources , AIT Austrian Institute of Technology GmbH , 2444 Seibersdorf , Austria.
  • Novarino G; Institute of Science and Technology (IST) Austria , 3400 Klosterneuburg , Austria.
  • Tournier N; UMR 1023 IMIV, Service Hospitalier Frédéric Joliot , CEA, Inserm, Univ. Paris Sud, CNRS, Université Paris-Saclay , 91450 Orsay , France.
  • Bauer M; Department of Clinical Pharmacology , Medical University of Vienna , 1090 Vienna , Austria.
  • Wanek T; Center for Health & Bioresources , AIT Austrian Institute of Technology GmbH , 2444 Seibersdorf , Austria.
  • Langer O; Center for Health & Bioresources , AIT Austrian Institute of Technology GmbH , 2444 Seibersdorf , Austria.
Mol Pharm ; 16(3): 1282-1293, 2019 03 04.
Article in En | MEDLINE | ID: mdl-30694684
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Blood-Brain Barrier / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Radiopharmaceuticals / Protein Kinase Inhibitors / Erlotinib Hydrochloride / ATP Binding Cassette Transporter, Subfamily G, Member 2 Type of study: Guideline Aspects: Implementation_research Limits: Animals Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2019 Document type: Article Affiliation country: Austria Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Blood-Brain Barrier / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Radiopharmaceuticals / Protein Kinase Inhibitors / Erlotinib Hydrochloride / ATP Binding Cassette Transporter, Subfamily G, Member 2 Type of study: Guideline Aspects: Implementation_research Limits: Animals Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2019 Document type: Article Affiliation country: Austria Country of publication: Estados Unidos