An insight into the whole transcriptome profile of four tissue-specific human mesenchymal stem cells.
Regen Med
; 14(9): 841-865, 2019 09 01.
Article
in En
| MEDLINE
| ID: mdl-30702025
Aim: Variations in the clinical outcomes using mesenchymal stem cells (MSCs) treatments exist, reflecting different origins and niches. To date, there is no consensus on the best source of MSCs most suitable to treat a specific disease. Methods: Total transcriptome analysis of human MSCs was performed. MSCs were isolated from two adult sources bone marrow, adipose tissue and two perinatal sources umbilical cord and placenta. Results: Each MSCs type possessed a unique expression pattern that reflects an advantage in terms of their potential therapeutic use. Advantages in immune modulation, neurogenesis and other aspects were found. Discussion: This study is a milestone for evidence-based choice of the type of MSCs used in the treatment of diseases.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene Expression Regulation
/
Gene Expression Profiling
/
Mesenchymal Stem Cells
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Regen Med
Year:
2019
Document type:
Article
Affiliation country:
Jordania
Country of publication:
Reino Unido