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A metabolic switch in proteasome inhibitor-resistant multiple myeloma ensures higher mitochondrial metabolism, protein folding and sphingomyelin synthesis.
Besse, Lenka; Besse, Andrej; Mendez-Lopez, Max; Vasickova, Katerina; Sedlackova, Miroslava; Vanhara, Petr; Kraus, Marianne; Bader, Jürgen; Ferreira, Renan B; Castellano, Ronald K; Law, Brian K; Driessen, Christoph.
Affiliation
  • Besse L; Experimental Oncology and Hematology, Department of Oncology and Hematology, St. Gallen Cantonal Hospital, St. Gallen, Switzerland Lenka.besse@kssg.ch.
  • Besse A; Experimental Oncology and Hematology, Department of Oncology and Hematology, St. Gallen Cantonal Hospital, St. Gallen, Switzerland.
  • Mendez-Lopez M; Experimental Oncology and Hematology, Department of Oncology and Hematology, St. Gallen Cantonal Hospital, St. Gallen, Switzerland.
  • Vasickova K; Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
  • Sedlackova M; Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
  • Vanhara P; Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
  • Kraus M; Experimental Oncology and Hematology, Department of Oncology and Hematology, St. Gallen Cantonal Hospital, St. Gallen, Switzerland.
  • Bader J; Experimental Oncology and Hematology, Department of Oncology and Hematology, St. Gallen Cantonal Hospital, St. Gallen, Switzerland.
  • Ferreira RB; Department of Chemistry, University of Florida, Gainesville, FL, USA.
  • Castellano RK; Department of Chemistry, University of Florida, Gainesville, FL, USA.
  • Law BK; UF-Health Cancer Center, University of Florida, Gainesville, FL, USA.
  • Driessen C; UF-Health Cancer Center, University of Florida, Gainesville, FL, USA.
Haematologica ; 104(9): e415-e419, 2019 09.
Article in En | MEDLINE | ID: mdl-30792209
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sphingomyelins / Drug Resistance, Neoplasm / Proteasome Inhibitors / Mitochondria / Multiple Myeloma Limits: Aged / Female / Humans / Middle aged Language: En Journal: Haematologica Year: 2019 Document type: Article Affiliation country: Suiza Country of publication: Italia
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sphingomyelins / Drug Resistance, Neoplasm / Proteasome Inhibitors / Mitochondria / Multiple Myeloma Limits: Aged / Female / Humans / Middle aged Language: En Journal: Haematologica Year: 2019 Document type: Article Affiliation country: Suiza Country of publication: Italia