Benzodifurans for biomedical applications: BZ4, a selective anti-proliferative and anti-amyloid lead compound.
Future Med Chem
; 11(4): 285-302, 2019 Feb.
Article
in En
| MEDLINE
| ID: mdl-30801198
ABSTRACT
Aim:
Our goal is to evaluate benzodifuran-based scaffolds for biomedical applications.Methodology:
We here explored the anticancer and anti-amyloid activities of a novel compound (BZ4) in comparison with other known benzodifuran analogs, previously studied in our group, and we have explored its ability to interact with different DNA model systems.Results:
BZ4 shows antiproliferative activity on different cancer cells; does not affect noncancerous control cells and alters the aggregation properties of ß-amyloid, as ascertained by circular dichroism, fluorescence spectroscopy and scanning electron microscopy analysis. An overall, qualitative picture on the mechanistic aspects related to the biological activities is discussed in light of the dynamic light scattering, UV, circular dichroism and fluorescence data, as well as of the metal ion-binding properties of BZ4.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Qualitative_research
Language:
En
Journal:
Future Med Chem
Year:
2019
Document type:
Article
Affiliation country:
Italia