Addressing systematic inconsistencies between in vitro and in vivo transcriptomic mode of action signatures.

McMullen, Patrick D; Pendse, Salil N; Black, Michael B; Mansouri, Kamel; Haider, Saad; Andersen, Melvin E; Clewell, Rebecca A

McMullen, Patrick D; Pendse, Salil N; Black, Michael B; Mansouri, Kamel; Haider, Saad; Andersen, Melvin E; Clewell, Rebecca A.

Affiliation

McMullen PD; ScitoVation, 100 Capitola Drive, Suite 106, Durham, NC 27713, United States of America. Electronic address: pmcmullen@scitovation.com.
Pendse SN; ScitoVation, 100 Capitola Drive, Suite 106, Durham, NC 27713, United States of America.
Black MB; ScitoVation, 100 Capitola Drive, Suite 106, Durham, NC 27713, United States of America.
Mansouri K; ScitoVation, 100 Capitola Drive, Suite 106, Durham, NC 27713, United States of America.
Haider S; ScitoVation, 100 Capitola Drive, Suite 106, Durham, NC 27713, United States of America.
Andersen ME; ScitoVation, 100 Capitola Drive, Suite 106, Durham, NC 27713, United States of America.
Clewell RA; ScitoVation, 100 Capitola Drive, Suite 106, Durham, NC 27713, United States of America; 21st Century Tox Consulting LLC, 125 S. Estes Drive, Unit 4494, Chapel Hill, NC 27515, United States of America.

Toxicol In Vitro ; 58: 1-12, 2019 Aug.

Article in En | MEDLINE | ID: mdl-30807807

Subject(s)
Key words

Biological pathway visualization; Chemical mode of action; MoAviz; TG-GATES; Toxicogenomics response; Transcriptomics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Profiling Type of study: Etiology_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Toxicol In Vitro Journal subject: TOXICOLOGIA Year: 2019 Document type: Article Country of publication: Reino Unido

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