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α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFß antibody to promote durable rejection and immunity in squamous cell carcinomas.
Dodagatta-Marri, E; Meyer, D S; Reeves, M Q; Paniagua, R; To, M D; Binnewies, M; Broz, M L; Mori, H; Wu, D; Adoumie, M; Del Rosario, R; Li, O; Buchmann, T; Liang, B; Malato, J; Arce Vargus, F; Sheppard, D; Hann, B C; Mirza, A; Quezada, S A; Rosenblum, M D; Krummel, M F; Balmain, A; Akhurst, R J.
Affiliation
  • Dodagatta-Marri E; Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA.
  • Meyer DS; Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA.
  • Reeves MQ; Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA.
  • Paniagua R; Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA.
  • To MD; Department of Dermatology, UCSF, San Francisco, CA, USA.
  • Binnewies M; Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA.
  • Broz ML; Department of Pathology, UCSF, San Francisco, CA, USA.
  • Mori H; Department of Pathology, UCSF, San Francisco, CA, USA.
  • Wu D; Center for Comparative Medicine UC Davis, Davis, CA, USA.
  • Adoumie M; Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA.
  • Del Rosario R; Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA.
  • Li O; Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA.
  • Buchmann T; Department of Medicine, UCSF, San Francisco, CA, USA.
  • Liang B; Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA.
  • Malato J; Xoma Corporation, Berkeley, CA, USA.
  • Arce Vargus F; Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA.
  • Sheppard D; Cancer Immunology Unit, Immune Regulation and Tumour Immunotherapy Lab, University College London, London, UK.
  • Hann BC; Xoma Corporation, Berkeley, CA, USA.
  • Mirza A; Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA.
  • Quezada SA; Department of Medicine, UCSF, San Francisco, CA, USA.
  • Rosenblum MD; Cancer Immunology Unit, Immune Regulation and Tumour Immunotherapy Lab, University College London, London, UK.
  • Krummel MF; Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA.
  • Balmain A; Department of Dermatology, UCSF, San Francisco, CA, USA.
  • Akhurst RJ; Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA, USA.
J Immunother Cancer ; 7(1): 62, 2019 03 04.
Article in En | MEDLINE | ID: mdl-30832732
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transforming Growth Factor beta / T-Lymphocytes, Regulatory / T-Lymphocytes, Helper-Inducer / Smad3 Protein Type of study: Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: J Immunother Cancer Year: 2019 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transforming Growth Factor beta / T-Lymphocytes, Regulatory / T-Lymphocytes, Helper-Inducer / Smad3 Protein Type of study: Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: J Immunother Cancer Year: 2019 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido