Antidepressants for the treatment of narcolepsy: A prospective study of 148 patients in northern China.
J Clin Neurosci
; 63: 27-31, 2019 May.
Article
in En
| MEDLINE
| ID: mdl-30837110
ABSTRACT
Narcolepsy is a life-long neurological disorder characterized by excessive daytime sleepiness (EDS) and cataplexy. At present, Sodium oxybate, modafinil, methylphenidate and other stimulants are recommended first-line therapies for narcolepsy but are difficult to obtain in China. One hundred forty-eight patients with narcolepsy were treated with antidepressants and administered the Epworth Sleepiness Scale (ESS) and the Maintenance of Wakefulness Test (MWT) before and after treatment from August 2012 to August 2017. The subjects were followed for 1-6â¯years after treatment. Improvement in sleepiness, cataplexy, cataplexy-like episodes, and antidepressant side effects were assessed. There were significant differences in the mean sleep latency (MSL) and sleep onset rapid eye movement periods (SOREMPs) in MWT and ESS scores, cataplexy and cataplexy-like episodes before and after treatment (pâ¯<â¯0.01). Venlafaxine demonstrated significantly greater improvements in MSL in the MWT (pâ¯<â¯0.01). Early awakenings and dry mouth were the most common adverse effects.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Venlafaxine Hydrochloride
/
Modafinil
/
Antidepressive Agents
/
Narcolepsy
Type of study:
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Clin Neurosci
Journal subject:
NEUROLOGIA
Year:
2019
Document type:
Article
Affiliation country:
China