The Effect of Antenatal Vaginal Progesterone Administration on Uterine, Umbilical, and Fetal Middle Cerebral Artery Doppler Flow: A Cohort Study.
Am J Perinatol
; 37(5): 491-496, 2020 04.
Article
in En
| MEDLINE
| ID: mdl-30866028
ABSTRACT
OBJECTIVE:
This study aimed to evaluate the effect of vaginal progesterone (P) administration during the second and third trimesters of pregnancy on Doppler velocimetry of uterine, umbilical, and middle cerebral vessels. STUDYDESIGN:
A prospective cohort study conducted on 80 women at risk for preterm labor. Uterine artery, umbilical artery, and middle cerebral artery (MCA) Doppler indices were measured before and after 1 week of administration of 200 mg twice daily vaginal P. The primary outcome parameter was the change of MCA pulsatility index (PI) after P administration. Secondary outcomes included changes in uterine artery and umbilical artery Doppler measurement.RESULTS:
There was no significant changes of umbilical artery resistance index (RI) (0.69 ± 0.049 vs. 0.68 ± 0.041), umbilical artery PI (1.14 ± 0.118 vs. 1.11 ± 0.116), uterine artery RI (0.66 ± 0.12 vs. 0.66 ± 0.107), uterine artery PI (1.00 ± 0.26 vs. 1.016 ± 0.24), and MCA PI (1.27 ± 0.18 vs. 1.26 ± 0.23) measurements before and after 1 week of P administration, respectively.CONCLUSION:
Administration of vaginal P has no significant effects on uterine artery, umbilical artery, and MCA Doppler indices.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Progesterone
/
Umbilical Arteries
/
Blood Flow Velocity
/
Ultrasonography, Doppler
/
Middle Cerebral Artery
/
Uterine Artery
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Am J Perinatol
Year:
2020
Document type:
Article
Affiliation country:
Egipto