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The Effect of Antenatal Vaginal Progesterone Administration on Uterine, Umbilical, and Fetal Middle Cerebral Artery Doppler Flow: A Cohort Study.
Maged, Ahmed M; Shoab, Amira Y; Hussein, Eman A; Alsawaf, Ahmed H; Mahmoud, Doaa S; AbdAllah, Ameer A; Dahab, Sherif; Darwish, Mohamed; Ali, Yahia Z; Badran, Haitham.
Affiliation
  • Maged AM; Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt.
  • Shoab AY; Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt.
  • Hussein EA; Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt.
  • Alsawaf AH; Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt.
  • Mahmoud DS; Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt.
  • AbdAllah AA; Department of Obstetrics and Gynecology, Minia University, Minia, Egypt.
  • Dahab S; Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt.
  • Darwish M; Department of Gynecology and Obstetrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
  • Ali YZ; Department of Gynecology and Obstetrics, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
  • Badran H; Department of Gynecology and Obstetrics, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Am J Perinatol ; 37(5): 491-496, 2020 04.
Article in En | MEDLINE | ID: mdl-30866028
ABSTRACT

OBJECTIVE:

This study aimed to evaluate the effect of vaginal progesterone (P) administration during the second and third trimesters of pregnancy on Doppler velocimetry of uterine, umbilical, and middle cerebral vessels. STUDY

DESIGN:

A prospective cohort study conducted on 80 women at risk for preterm labor. Uterine artery, umbilical artery, and middle cerebral artery (MCA) Doppler indices were measured before and after 1 week of administration of 200 mg twice daily vaginal P. The primary outcome parameter was the change of MCA pulsatility index (PI) after P administration. Secondary outcomes included changes in uterine artery and umbilical artery Doppler measurement.

RESULTS:

There was no significant changes of umbilical artery resistance index (RI) (0.69 ± 0.049 vs. 0.68 ± 0.041), umbilical artery PI (1.14 ± 0.118 vs. 1.11 ± 0.116), uterine artery RI (0.66 ± 0.12 vs. 0.66 ± 0.107), uterine artery PI (1.00 ± 0.26 vs. 1.016 ± 0.24), and MCA PI (1.27 ± 0.18 vs. 1.26 ± 0.23) measurements before and after 1 week of P administration, respectively.

CONCLUSION:

Administration of vaginal P has no significant effects on uterine artery, umbilical artery, and MCA Doppler indices.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Progesterone / Umbilical Arteries / Blood Flow Velocity / Ultrasonography, Doppler / Middle Cerebral Artery / Uterine Artery Type of study: Diagnostic_studies / Etiology_studies / Observational_studies Limits: Adult / Female / Humans / Pregnancy Language: En Journal: Am J Perinatol Year: 2020 Document type: Article Affiliation country: Egipto

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Progesterone / Umbilical Arteries / Blood Flow Velocity / Ultrasonography, Doppler / Middle Cerebral Artery / Uterine Artery Type of study: Diagnostic_studies / Etiology_studies / Observational_studies Limits: Adult / Female / Humans / Pregnancy Language: En Journal: Am J Perinatol Year: 2020 Document type: Article Affiliation country: Egipto