Pharmacokinetics: Unique Challenges in Blood Monitoring for Oncology Nurses.
Clin J Oncol Nurs
; 23(2): 191-196, 2019 04 01.
Article
in En
| MEDLINE
| ID: mdl-30880803
ABSTRACT
BACKGROUND:
Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion of drugs. Many chemotherapeutic agents have a sensitive PK index, in which a small margin in blood concentrations is the difference between nontherapeutic, therapeutic, and adverse outcomes.OBJECTIVES:
This article will provide an overview of evidence-based approaches to the collection of PK samples, monitoring of PK levels, and the resulting management of patients undergoing PK testing.METHODS:
A case study involving busulfan, an alkylating agent used in the pre-stem cell transplantation setting, will highlight the cross-contamination of samples while a drug is being infused through a central venous catheter with PK sample collection from a proximal peripherally inserted central catheter. The influence of false elevations in drug concentrations on PK-guided dose adjustments will also be emphasized.FINDINGS:
Imprecise blood collections or cross-contamination of samples may lead to inaccurate drug concentration results and, subsequently, undesired low or high drug dosage calculations.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Busulfan
/
Drug Monitoring
/
Antineoplastic Agents, Alkylating
/
Neoplasms
Limits:
Aged
/
Humans
/
Male
Language:
En
Journal:
Clin J Oncol Nurs
Journal subject:
ENFERMAGEM
/
NEOPLASIAS
Year:
2019
Document type:
Article