Over-expression of low-density lipoprotein receptor-related Protein-1 is associated with poor prognosis and invasion in pancreatic ductal adenocarcinoma.
Pancreatology
; 19(3): 429-435, 2019 Apr.
Article
in En
| MEDLINE
| ID: mdl-30902418
ABSTRACT
BACKGROUND:
Low-density lipoprotein receptor-Related Protein-1 (LRP-1) has been reported to involve in tumor development. However, its role in pancreatic cancer has not been elucidated. The present study was designed to evaluate the expression of LRP-1 in Pancreatic Ductal Adenocarcinoma Cancer (PDAC) as well as its association with prognosis.METHODS:
Here, 478 pancreatic cancers were screened for suitable primary PDAC tumors. The samples were analyzed using qRT-PCR, western blotting, and Immunohistochemistry (IHC) staining as well as LRP-1 expression in association with clinicopathological features.RESULTS:
The relative LRP-1 mRNA expression was up-regulated in 82.3% (42/51) of the PDAC tumors and its expression (3.72⯱â¯1.25) was significantly higher than that in pancreatic normal margins (1.0⯱â¯0.23, Pâ¯<â¯0.05). This up-regulation was stage dependent (Pâ¯<â¯0.05). A similar pattern of LRP-1 protein expression was discovered (Pâ¯<â¯0.05). The high expression of LRP-1 in the PDAC tissues was strongly correlated with the low survival time (Pâ¯=â¯0.001), TNM classification (Pâ¯=â¯0.001), low differentiations status (Pâ¯=â¯0.001), lymphatic invasion (Pâ¯=â¯0.01) and Perineural Invasion (PNI) status (Pâ¯=â¯0.001).CONCLUSIONS:
Our finding for the first time revealed that LRP-1 expression inversely associated with poor prognosis and PNI in PDAC tumor.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pancreatic Neoplasms
/
Adenocarcinoma
/
Carcinoma, Pancreatic Ductal
/
Low Density Lipoprotein Receptor-Related Protein-1
/
Neoplasm Invasiveness
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Pancreatology
Journal subject:
ENDOCRINOLOGIA
/
GASTROENTEROLOGIA
Year:
2019
Document type:
Article
Affiliation country:
Irán