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Mitochondria and nucleus delivery of active form of 10-hydroxycamptothecin with dual shell to precisely treat colorectal cancer.
Li, Huai-Qiu; Ye, Wei-Liang; Huan, Meng-Lei; Cheng, Ying; Liu, Dao-Zhou; Cui, Han; Liu, Miao; Zhang, Bang-le; Mei, Qi-Bing; Zhou, Si-Yuan.
Affiliation
  • Li HQ; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, PR China.
  • Ye WL; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, PR China.
  • Huan ML; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, PR China.
  • Cheng Y; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, PR China.
  • Liu DZ; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, PR China.
  • Cui H; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, PR China.
  • Liu M; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, PR China.
  • Zhang BL; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, PR China.
  • Mei QB; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Fourth Military Medical University, Xi'an 710032, PR China.
  • Zhou SY; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, PR China.
Nanomedicine (Lond) ; 14(8): 1011-1032, 2019 04.
Article in En | MEDLINE | ID: mdl-30925116
AIM: The objective of this study was to deliver a ring-closed form of 10-hydroxycamptothecin (HCPT) to the mitochondria and nucleus to treat colorectal cancer. MATERIALS & METHODS: HCPT-loaded nanoparticle HCPT@PLGA-PEG2k-triphenylphosphonium/PLGA-hyd-PEG4k-folic acid (PT/PHF) and HCPT@PT/PLGA-SS-PEG4k-folic acid (PSF) were prepared by using emulsion-solvent evaporation method. RESULTS: In vitro experimental results indicated HCPT@PT/PHF and HCPT@PT/PSF maintained a large amount of HCPT in active form, and delivered more HCPT to the nucleus and mitochondria of the tumor cell, which resulted in the enhancement of cytotoxicity of HCPT. In vivo experimental results indicated that HCPT@PT/PHF and HCPT@PT/PSF delivered more ring-closed form of HCPT to tumor tissue, which led to strong antitumor activity. CONCLUSION: HCPT@PT/PHF and HCPT@PT/PSF could enhance therapeutic efficacy of HCPT to colorectal cancer.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Camptothecin / Drug Carriers / Colorectal Neoplasms / Cell Nucleus / Mitochondria Limits: Animals / Humans Language: En Journal: Nanomedicine (Lond) Year: 2019 Document type: Article Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Camptothecin / Drug Carriers / Colorectal Neoplasms / Cell Nucleus / Mitochondria Limits: Animals / Humans Language: En Journal: Nanomedicine (Lond) Year: 2019 Document type: Article Country of publication: Reino Unido