Pro-GA, a Novel Inhibitor of γ-Glutamylcyclotransferase, Suppresses Human Bladder Cancer Cell Growth.
Anticancer Res
; 39(4): 1893-1898, 2019 Apr.
Article
in En
| MEDLINE
| ID: mdl-30952730
ABSTRACT
BACKGROUND/AIM:
γ-Glutamylcyclotransferase (GGCT), a key enzyme involved in glutathione metabolism, catalyzes a specific reaction that generates 5-oxoproline and free amino acids from the γ-glutamyl peptide. Inhibition of GGCT is a promising therapeutic strategy for the treatment of various cancers. MATERIALS ANDMETHODS:
Immuno-histochemistry was used to evaluate GGCT expression in bladder tumors. The growth inhibitory effect of pro-GA, a novel GGCT inhibitor, in the presence or absence of mitomycin C (MMC) was assessed in three distinct bladder cancer cell lines.RESULTS:
Over half of the clinical bladder tumor samples overexpressed GGCT. Pro-GA reduced the growth of all bladder cancer cell lines in a dose-dependent manner, and increased the anti-tumor effect of MMC.CONCLUSION:
Inhibition of GGCT using pro-GA provides a novel therapeutic strategy for the treatment of bladder cancers.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Urinary Bladder Neoplasms
/
Cell Proliferation
/
Enzyme Inhibitors
/
Gamma-Glutamylcyclotransferase
/
Antineoplastic Agents
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Anticancer Res
Year:
2019
Document type:
Article
Affiliation country:
Japón