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Donghaesulfins A and B, Dimeric Benz[ a]anthracene Thioethers from Volcanic Island Derived Streptomyces sp.
Bae, Munhyung; An, Joon Soo; Bae, Eun Seo; Oh, Jedo; Park, So Hyun; Lim, Yeonjung; Ban, Yeon Hee; Kwon, Yun; Cho, Jang-Cheon; Yoon, Yeo Joon; Lee, Sang Kook; Shin, Jongheon; Oh, Dong-Chan.
Affiliation
  • Bae M; Natural Products Research Institute, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.
  • An JS; Natural Products Research Institute, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.
  • Bae ES; Natural Products Research Institute, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.
  • Oh J; Natural Products Research Institute, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.
  • Park SH; Natural Products Research Institute, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.
  • Lim Y; Department of Biological Sciences , Inha University , Incheon 22212 , Republic of Korea.
  • Ban YH; Department of Chemistry and Nanoscience , Ewha Womans University , Seoul 03760 , Republic of Korea.
  • Kwon Y; Natural Products Research Institute, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.
  • Cho JC; Department of Biological Sciences , Inha University , Incheon 22212 , Republic of Korea.
  • Yoon YJ; Department of Chemistry and Nanoscience , Ewha Womans University , Seoul 03760 , Republic of Korea.
  • Lee SK; Natural Products Research Institute, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.
  • Shin J; Natural Products Research Institute, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.
  • Oh DC; Natural Products Research Institute, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.
Org Lett ; 21(10): 3635-3639, 2019 05 17.
Article in En | MEDLINE | ID: mdl-31033298
ABSTRACT
The chemical analysis of a Streptomyces strain, from a Korean volcanic island, discovered new benz[ a]anthracene dimers linked by a thioether bond. The structures of donghaesulfins A and B (1 and 2) were elucidated by spectroscopic analysis including energy-dispersive X-ray. Their configurations were determined by ROESY NMR data, DP4 calculations, the modified Mosher's method, and ECD calculations. Donghaesulfins A (1) induced quinone reductase, whereas donghaesulfin B (2) displayed antiangiogenesis activity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptomyces / Sulfides / Anthracenes Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2019 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptomyces / Sulfides / Anthracenes Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2019 Document type: Article