Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation.
Cell Rep
; 27(5): 1461-1471.e4, 2019 04 30.
Article
in En
| MEDLINE
| ID: mdl-31042473
ABSTRACT
B cell lymphoma-6 (BCL6) is highly expressed in germinal center B cells, but how its expression is maintained is still not completely clear. Aryl hydrocarbon receptor interacting protein (AIP) is a co-chaperone of heat shock protein 90. Deletion of Aip in B cells decreased BCL6 expression, reducing germinal center B cells and diminishing adaptive immune responses. AIP was required for optimal AKT signaling in response to B cell receptor stimulation, and AIP protected BCL6 from ubiquitin-mediated proteasomal degradation by the E3-ubiquitin ligase FBXO11 by binding to the deubiquitinase UCHL1, thus helping to maintain the expression of BCL6. AIP was highly expressed in primary diffuse large B cell lymphomas compared to healthy tissue and other tumors. Our findings describe AIP as a positive regulator of BCL6 expression with implications for the pathobiology of diffuse large B cell lymphoma.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
B-Lymphocytes
/
Lymphoma, Large B-Cell, Diffuse
/
Germinal Center
/
Intracellular Signaling Peptides and Proteins
/
Proto-Oncogene Proteins c-bcl-6
Limits:
Adult
/
Aged
/
Aged80
/
Animals
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Cell Rep
Year:
2019
Document type:
Article
Affiliation country:
Reino Unido