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Bridging the gap: Mechanisms of plasticity and repair after pediatric TBI.
Sta Maria, Naomi S; Sargolzaei, Saman; Prins, Mayumi L; Dennis, Emily L; Asarnow, Robert F; Hovda, David A; Harris, Neil G; Giza, Christopher C.
Affiliation
  • Sta Maria NS; Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, University of Southern California, 1501 San Pablo Street, ZNI115, Los Angeles, CA 90033, United States of America. Electronic address: nstamari@usc.edu.
  • Sargolzaei S; UCLA Brain Injury Research Center, Department of Neurosurgery, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562, 5th Floor, Los Angeles, CA 90095-6901, United States of America. Electronic address: ssargolzaei@mednet.ucla.edu.
  • Prins ML; UCLA Brain Injury Research Center, Department of Neurosurgery, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562, 5th Floor, Los Angeles, CA 90095-6901, United States of America; Steve Tisch BrainSPORT Program, University of California at Los Angeles, Los Angeles, CA, Uni
  • Dennis EL; Brigham and Women's Hospital/Harvard University and Department of Psychology, Stanford University, 1249 Boylston Street, Boston, MA 02215, United States of America. Electronic address: edennis@bwh.harvard.edu.
  • Asarnow RF; Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Box 951759, 760 Westwood Plaza, 48-240C Semel Institute, Los Angeles, CA 90095-1759, United States of America. Electronic address: rasarnow@mednet.ucla.edu.
  • Hovda DA; UCLA Brain Injury Research Center, Department of Neurosurgery, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562, 5th Floor, Los Angeles, CA 90095-6901, United States of America; Department of Medical and Molecular Pharmacology, University of California at Los Angeles, Bo
  • Harris NG; UCLA Brain Injury Research Center, Department of Neurosurgery, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562, 5th Floor, Los Angeles, CA 90095-6901, United States of America; Intellectual Development and Disabilities Research Center, David Geffen School of Medicine, U
  • Giza CC; UCLA Brain Injury Research Center, Department of Neurosurgery, University of California at Los Angeles, Box 956901, 300 Stein Plaza, Ste 562, 5th Floor, Los Angeles, CA 90095-6901, United States of America; Steve Tisch BrainSPORT Program, University of California at Los Angeles, Los Angeles, CA, Uni
Exp Neurol ; 318: 78-91, 2019 08.
Article in En | MEDLINE | ID: mdl-31055004
ABSTRACT
Traumatic brain injury is the leading cause of death and disability in the United States, and may be associated with long lasting impairments into adulthood. The multitude of ongoing neurobiological processes that occur during brain maturation confer both considerable vulnerability to TBI but may also provide adaptability and potential for recovery. This review will examine and synthesize our current understanding of developmental neurobiology in the context of pediatric TBI. Delineating this biology will facilitate more targeted initial care, mechanism-based therapeutic interventions and better long-term prognostication and follow-up.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recovery of Function / Brain Injuries, Traumatic / Nerve Regeneration / Neuronal Plasticity Limits: Child / Child, preschool / Humans / Infant / Newborn Language: En Journal: Exp Neurol Year: 2019 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recovery of Function / Brain Injuries, Traumatic / Nerve Regeneration / Neuronal Plasticity Limits: Child / Child, preschool / Humans / Infant / Newborn Language: En Journal: Exp Neurol Year: 2019 Document type: Article