Exendin-4 analogs in insulinoma theranostics.
J Labelled Comp Radiopharm
; 62(10): 656-672, 2019 08.
Article
in En
| MEDLINE
| ID: mdl-31070270
ABSTRACT
Insulinomas, neuroendocrine tumors arising from pancreatic beta cells, often show overexpression of the glucagon-like peptide-1 receptor. Therefore, imaging with glucagon-like peptide analog exendin-4 can be used for diagnosis and preoperative localization. This review presents an overview of the development and clinical implementation of exendin-based tracers for nuclear imaging, and the potential use of exendin-4 based tracers for optical imaging and therapeutic applications such as peptide receptor radionuclide therapy or targeted photodynamic therapy.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diagnostic Imaging
/
Exenatide
/
Insulinoma
Type of study:
Diagnostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
J Labelled Comp Radiopharm
Year:
2019
Document type:
Article
Affiliation country:
Países Bajos