Correlation between MMP-2 gene polymorphism and cataract susceptibility.

ABSTRACT

OBJECTIVE: To investigate the correlation between matrix metalloproteinase-2 (MMP-2) gene polymorphism and cataract. PATIENTS AND METHODS: 104 cataract patients and 100 healthy subjects were enrolled and assigned to the observation group and control group, respectively. General clinical data of the enrolled subjects were collected. The inflammatory factors were detected, and the rs243865 polymorphism of MMP-2 gene was detected using the TaqMan-MGB probe. RESULTS: The levels of interleukin-6 (IL-6), IL-1ß, C-reactive protein (CRP), and tumor necrosis factor-1α (TNF-1α) in the observation group were higher than those in the control group (p<0.05). There were significant differences in the genotype and allele distribution frequency between the two groups (p<0.05). In the genetic model analysis, the additive model was remarkably different between the two groups (p<0.05). However, the recessive model and dominant model were not different between the two groups (p>0.05). CONCLUSIONS: Cataract is correlated with inflammatory factors, and the rs243865 polymorphism of MMP-2 gene has a correlation with the incidence of cataract.