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An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice.
Eyer, Ludek; Nougairède, Antoine; Uhlírová, Marie; Driouich, Jean-Sélim; Zouharová, Darina; Valdés, James J; Haviernik, Jan; Gould, Ernest A; De Clercq, Erik; de Lamballerie, Xavier; Ruzek, Daniel.
Affiliation
  • Eyer L; Department of Virology, Veterinary Research Institute, Brno, Czech Republic.
  • Nougairède A; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic.
  • Uhlírová M; Unité des Virus Émergents (Aix-Marseille Univ-IRD 190-Inserm 1207-IHU Méditerranée Infection), Marseille, France.
  • Driouich JS; Department of Virology, Veterinary Research Institute, Brno, Czech Republic.
  • Zouharová D; Unité des Virus Émergents (Aix-Marseille Univ-IRD 190-Inserm 1207-IHU Méditerranée Infection), Marseille, France.
  • Valdés JJ; Department of Virology, Veterinary Research Institute, Brno, Czech Republic.
  • Haviernik J; Department of Virology, Veterinary Research Institute, Brno, Czech Republic.
  • Gould EA; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic.
  • De Clercq E; Department of Virology, Veterinary Research Institute, Brno, Czech Republic.
  • de Lamballerie X; Unité des Virus Émergents (Aix-Marseille Univ-IRD 190-Inserm 1207-IHU Méditerranée Infection), Marseille, France.
  • Ruzek D; KU Leuven, Rega Institute of Medical Research, Leuven, Belgium.
J Virol ; 93(16)2019 08 15.
Article in En | MEDLINE | ID: mdl-31142664
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Adenine / Viral Nonstructural Proteins / Amino Acid Substitution / Drug Resistance, Viral / Encephalitis, Tick-Borne / Encephalitis Viruses, Tick-Borne / Mutation Limits: Animals Language: En Journal: J Virol Year: 2019 Document type: Article Affiliation country: República Checa Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Adenine / Viral Nonstructural Proteins / Amino Acid Substitution / Drug Resistance, Viral / Encephalitis, Tick-Borne / Encephalitis Viruses, Tick-Borne / Mutation Limits: Animals Language: En Journal: J Virol Year: 2019 Document type: Article Affiliation country: República Checa Country of publication: Estados Unidos