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Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.
Yamamoto, Atsushi; Hester, Joanna; Macklin, Philip S; Kawai, Kento; Uchiyama, Masateru; Biggs, Daniel; Bishop, Tammie; Bull, Katherine; Cheng, Xiaotong; Cawthorne, Eleanor; Coleman, Mathew L; Crockford, Tanya L; Davies, Ben; Dow, Lukas E; Goldin, Rob; Kranc, Kamil; Kudo, Hiromi; Lawson, Hannah; McAuliffe, James; Milward, Kate; Scudamore, Cheryl L; Soilleux, Elizabeth; Issa, Fadi; Ratcliffe, Peter J; Pugh, Chris W.
Affiliation
  • Yamamoto A; Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Hester J; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
  • Macklin PS; Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Kawai K; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
  • Uchiyama M; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
  • Biggs D; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
  • Bishop T; Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Bull K; Henry Wellcome Building for Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Cheng X; Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Cawthorne E; Henry Wellcome Building for Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Coleman ML; Henry Wellcome Building for Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Crockford TL; Henry Wellcome Building for Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Davies B; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
  • Dow LE; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA.
  • Goldin R; Department of Cellular Pathology, Imperial College London, London, United Kingdom.
  • Kranc K; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
  • Kudo H; Department of Cellular Pathology, Imperial College London, London, United Kingdom.
  • Lawson H; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
  • McAuliffe J; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Milward K; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
  • Scudamore CL; Veterinary Pathology, MRC Harwell, Mary Lyon Centre, Harwell Campus, Oxford, United Kingdom.
  • Soilleux E; Department of Pathology, School of Biological Sciences, University of Cambridge, Cambridge, United Kingdom.
  • Issa F; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
  • Ratcliffe PJ; Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Pugh CW; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
J Clin Invest ; 129(9): 3640-3656, 2019 06 04.
Article in En | MEDLINE | ID: mdl-31162141
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / T-Lymphocytes, Regulatory / RNA Interference / Hypoxia-Inducible Factor-Proline Dioxygenases Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: J Clin Invest Year: 2019 Document type: Article Affiliation country: Reino Unido
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / T-Lymphocytes, Regulatory / RNA Interference / Hypoxia-Inducible Factor-Proline Dioxygenases Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: J Clin Invest Year: 2019 Document type: Article Affiliation country: Reino Unido