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Rearranged iridal-type triterpenoids from Iris tectorum.
Zhang, Chun-Lei; Wang, Yan; Zhao, Fang; Liu, Yan-Fei; Shi, Guo-Ru; Chen, Ruo-Yun; Yu, De-Quan; Cao, Zheng-Yu.
Affiliation
  • Zhang CL; State Key Laboratory of Natural Medicines & Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, People's Republic of China; State Key Laboratory of Bioactive Substanc
  • Wang Y; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • Zhao F; State Key Laboratory of Natural Medicines & Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, People's Republic of China.
  • Liu YF; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • Shi GR; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • Chen RY; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
  • Yu DQ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address: dqyu@imm.ac.cn.
  • Cao ZY; State Key Laboratory of Natural Medicines & Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, People's Republic of China. Electronic address: zycao@cpu.edu.cn.
Fitoterapia ; 137: 104193, 2019 Sep.
Article in En | MEDLINE | ID: mdl-31175949
Three new iridal-type triterpenoids (1-3) featuring a rearranged homofarnesylside chain were isolated from the rhizomes of Iris tectorum. Compounds 2 and 3 were found to be a pair of epimers. Their structures were elucidated on the basis of comprehensive spectroscopic analysis. A possible biosynthetic pathway for them was postulated. Moreover, the mixture of compounds 2 and 3 exhibited moderate neuroprotective activity against serum deprivation-induced PC12 cell death.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Neuroprotective Agents / Iris Plant Limits: Animals Country/Region as subject: Asia Language: En Journal: Fitoterapia Year: 2019 Document type: Article Country of publication: Países Bajos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Neuroprotective Agents / Iris Plant Limits: Animals Country/Region as subject: Asia Language: En Journal: Fitoterapia Year: 2019 Document type: Article Country of publication: Países Bajos