Hypoxia and Metabolism in Metastasis.
Adv Exp Med Biol
; 1136: 87-95, 2019.
Article
in En
| MEDLINE
| ID: mdl-31201718
ABSTRACT
The hypoxic microenvironment is one of the major features of solid tumors, which regulates cell malignancy in multiple ways. As a response to hypoxia, a large number of target genes involved in cell growth, metabolism, metastasis and immunity are activated in cancer cells. Hypoxia-inducible factor 1 (HIF-1), as a heterodimeric DNA-binding complex, is comprised of a constitutively expressed HIF-1ß subunit and an oxygen sensitive HIF-1α subunit, thus, adapts to decreased oxygen availability as a transcriptional factor. HIF-1 regulates many genes involved in tumorigenesis. Here, we focus on cancer cell metabolism and metastasis regulated by hypoxia.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tumor Hypoxia
/
Neoplasm Metastasis
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Adv Exp Med Biol
Year:
2019
Document type:
Article
Affiliation country:
China