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Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.
Johnson, Eachan O; LaVerriere, Emily; Office, Emma; Stanley, Mary; Meyer, Elisabeth; Kawate, Tomohiko; Gomez, James E; Audette, Rebecca E; Bandyopadhyay, Nirmalya; Betancourt, Natalia; Delano, Kayla; Da Silva, Israel; Davis, Joshua; Gallo, Christina; Gardner, Michelle; Golas, Aaron J; Guinn, Kristine M; Kennedy, Sofia; Korn, Rebecca; McConnell, Jennifer A; Moss, Caitlin E; Murphy, Kenan C; Nietupski, Raymond M; Papavinasasundaram, Kadamba G; Pinkham, Jessica T; Pino, Paula A; Proulx, Megan K; Ruecker, Nadine; Song, Naomi; Thompson, Matthew; Trujillo, Carolina; Wakabayashi, Shoko; Wallach, Joshua B; Watson, Christopher; Ioerger, Thomas R; Lander, Eric S; Hubbard, Brian K; Serrano-Wu, Michael H; Ehrt, Sabine; Fitzgerald, Michael; Rubin, Eric J; Sassetti, Christopher M; Schnappinger, Dirk; Hung, Deborah T.
Affiliation
  • Johnson EO; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • LaVerriere E; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA.
  • Office E; Department of Genetics, Harvard Medical School, Boston, MA, USA.
  • Stanley M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Meyer E; Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA, USA.
  • Kawate T; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Gomez JE; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Audette RE; Rush University Medical Center, Chicago, IL, USA.
  • Bandyopadhyay N; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Betancourt N; Department of Biochemistry, Stanford University, Stanford, CA, USA.
  • Delano K; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Da Silva I; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA.
  • Davis J; Department of Genetics, Harvard Medical School, Boston, MA, USA.
  • Gallo C; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Gardner M; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  • Golas AJ; Saint Louis University School of Medicine, St Louis, MO, USA.
  • Guinn KM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Kennedy S; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.
  • Korn R; Regeneron Pharmaceuticals, Tarrytown, NY, USA.
  • McConnell JA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Moss CE; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.
  • Murphy KC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Nietupski RM; Regulatory and Quality Solutions LLC, Braintree, MA, USA.
  • Papavinasasundaram KG; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Pinkham JT; Boston University School of Medicine, Boston, MA, USA.
  • Pino PA; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  • Proulx MK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Ruecker N; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  • Song N; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Thompson M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Trujillo C; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.
  • Wakabayashi S; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.
  • Wallach JB; Yale School of Medicine, New Haven, CT, USA.
  • Watson C; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.
  • Ioerger TR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Lander ES; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.
  • Hubbard BK; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
  • Serrano-Wu MH; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.
  • Ehrt S; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.
  • Fitzgerald M; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.
  • Rubin EJ; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.
  • Sassetti CM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Schnappinger D; Caribou Biosciences, Berkeley, CA, USA.
  • Hung DT; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA.
Nature ; 571(7763): 72-78, 2019 07.
Article in En | MEDLINE | ID: mdl-31217586
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microbial Sensitivity Tests / Gene Deletion / Small Molecule Libraries / Drug Discovery / Mycobacterium tuberculosis / Antitubercular Agents Type of study: Prognostic_studies Language: En Journal: Nature Year: 2019 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microbial Sensitivity Tests / Gene Deletion / Small Molecule Libraries / Drug Discovery / Mycobacterium tuberculosis / Antitubercular Agents Type of study: Prognostic_studies Language: En Journal: Nature Year: 2019 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido