Hypoxia signaling in human diseases and therapeutic targets.
Exp Mol Med
; 51(6): 1-13, 2019 06 20.
Article
in En
| MEDLINE
| ID: mdl-31221962
ABSTRACT
Since the discovery of hypoxia-inducible factor (HIF), numerous studies on the hypoxia signaling pathway have been performed. The role of HIF stabilization during hypoxia has been extended from the induction of a single gene erythropoietin to the upregulation of a couple of hundred downstream targets, which demonstrates the complexity and importance of the HIF signaling pathway. Accordingly, HIF and its downstream targets are emerging as novel therapeutic options to treat various organ injuries. In this review, we discuss the current understanding of HIF signaling in four different organ systems, including the heart, lung, liver, and kidney. We also discuss the divergent roles of HIF in acute and chronic disease conditions and their revealed functions. Finally, we introduce some of the efforts that are being performed to translate our current knowledge in hypoxia signaling to clinical medicine.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Heart Diseases
/
Kidney Diseases
/
Liver Diseases
/
Lung Diseases
/
Hypoxia
Limits:
Animals
/
Humans
Language:
En
Journal:
Exp Mol Med
Journal subject:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Year:
2019
Document type:
Article