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Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi® and Epclusa®.
Link, John O; Taylor, James G; Trejo-Martin, Alejandra; Kato, Darryl; Katana, Ashley A; Krygowski, Evan S; Yang, Zheng-Yu; Zipfel, Sheila; Cottell, Jeromy J; Bacon, Elizabeth M; Tran, Chinh V; Yang, Cheng Y; Wang, Yujin; Wang, Kelly W; Zhao, Guangyu; Cheng, Guofeng; Tian, Yang; Gong, Ruoyu; Lee, Yu-Jen; Yu, Mei; Gorman, Eric; Mogalian, Erik; Perry, Jason K.
Affiliation
  • Link JO; Medicinal Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States. Electronic address: john.link@gilead.com.
  • Taylor JG; Medicinal Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Trejo-Martin A; Medicinal Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Kato D; Medicinal Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Katana AA; Medicinal Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Krygowski ES; Medicinal Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Yang ZY; Medicinal Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Zipfel S; Medicinal Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Cottell JJ; Medicinal Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Bacon EM; Medicinal Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Tran CV; Medicinal Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Yang CY; Drug Metabolism, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Wang Y; Drug Metabolism, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Wang KW; Drug Metabolism, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Zhao G; Drug Metabolism, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Cheng G; Biology, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Tian Y; Biology, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Gong R; Biology, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Lee YJ; Biology, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Yu M; Biology, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Gorman E; Formulation and Process Development, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Mogalian E; Formulation and Process Development, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
  • Perry JK; Structural Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, United States.
Bioorg Med Chem Lett ; 29(16): 2415-2427, 2019 08 15.
Article in En | MEDLINE | ID: mdl-31230974
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Protease Inhibitors / Carbamates / Viral Nonstructural Proteins / Hepacivirus / Drug Discovery / Heterocyclic Compounds, 4 or More Rings Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Document type: Article Country of publication: Reino Unido
Fulltext
Add to My VHL
Print
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Protease Inhibitors / Carbamates / Viral Nonstructural Proteins / Hepacivirus / Drug Discovery / Heterocyclic Compounds, 4 or More Rings Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Document type: Article Country of publication: Reino Unido