Serum level of advanced oxidation protein products (AOPPs) in patients with Henoch-Schonlein purpura and its relationship with aberrant glycosylation of IgA1 and Cosmc mRNA expression.
Int J Dermatol
; 58(9): 1092-1097, 2019 Sep.
Article
in En
| MEDLINE
| ID: mdl-31250447
ABSTRACT
BACKGROUND:
Henoch-Schonlein purpura (HSP) is a systemic small vessel vasculitis that is mainly caused by IgA1-type immune complex deposition. Advanced oxidation protein products (AOPPs) are specific markers of protein oxidation.OBJECTIVE:
To explore the role of AOPPs in the pathogenesis of HSP.METHODS:
There are 51 HSP patients who were divided into four subgroups (i) skin type - 20 cases; (ii) joint type - 8 cases; (iii) abdominal type - 12 cases; (iv) renal type - 11 cases; and 18 healthy volunteers were enrolled as controls. The serum levels of AOPPs and Gd-IgA1 were quantified by an HAA-lectin-based ELISA. The Cosmc mRNA expression in peripheral B lymphocytes was measured by RT-PCR.RESULTS:
1. Advanced oxidation protein products in different subgroups of HSP patients are all higher than the controls, while the renal-type subgroup is the highest and the skin-type subgroup is the lowest. 2. Spearman correlation analysis shows that (i) AOPPs and Gd-IgA1 in HSP patients are positively correlated; both of them are positively correlated with the disease severity scores; (ii) AOPPs are negatively correlated with the relative expression value (RQ) of Cosmc mRNA.CONCLUSION:
Advanced oxidation protein products play an important role in the pathogenesis of HSP, especially in renal-type patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
IgA Vasculitis
/
Immunoglobulin A
/
Molecular Chaperones
/
Advanced Oxidation Protein Products
Type of study:
Diagnostic_studies
/
Observational_studies
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
En
Journal:
Int J Dermatol
Year:
2019
Document type:
Article
Affiliation country:
China