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Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type 2 diabetes.
Diamanti, Klev; Cavalli, Marco; Pan, Gang; Pereira, Maria J; Kumar, Chanchal; Skrtic, Stanko; Grabherr, Manfred; Risérus, Ulf; Eriksson, Jan W; Komorowski, Jan; Wadelius, Claes.
Affiliation
  • Diamanti K; Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
  • Cavalli M; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Pan G; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Pereira MJ; Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden.
  • Kumar C; Translational Science & Experimental Medicine, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Skrtic S; Karolinska Institutet/AstraZeneca Integrated CardioMetabolic Center (KI/AZ ICMC), Department of Medicine, Novum, Huddinge, Sweden.
  • Grabherr M; Pharmaceutical Technology & Development, AstraZeneca AB, Gothenburg, Sweden.
  • Risérus U; Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Eriksson JW; Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
  • Komorowski J; Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
  • Wadelius C; Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden.
Sci Rep ; 9(1): 9653, 2019 07 04.
Article in En | MEDLINE | ID: mdl-31273253
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prediabetic State / Lysophosphatidylcholines / Biomarkers / Carnitine / Diabetes Mellitus, Type 2 / Metabolome Type of study: Observational_studies / Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Sci Rep Year: 2019 Document type: Article Affiliation country: Suecia Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prediabetic State / Lysophosphatidylcholines / Biomarkers / Carnitine / Diabetes Mellitus, Type 2 / Metabolome Type of study: Observational_studies / Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Sci Rep Year: 2019 Document type: Article Affiliation country: Suecia Country of publication: Reino Unido