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UVEITIS CAUSED BY TREATMENT FOR MALIGNANT MELANOMA: A CASE SERIES.
Whist, Eline; Symes, Richard J; Chang, John H; Chowdhury, Vivek; Lim, Li-Anne; Grigg, John R; Lin, Ming-Lee; Karaconji, Tanya; Giblin, Michael; Symons, Andrew; Lim, Lyndell L; McCluskey, Peter J.
Affiliation
  • Whist E; Sydney Eye Hospital, Sydney, New South Wales, Australia.
  • Symes RJ; Sydney Eye Hospital, Sydney, New South Wales, Australia.
  • Chang JH; Save Sight Institute, Faculty of Medicine and Health, Sydney University, Sydney, New South Wales, Australia.
  • Chowdhury V; Retina and Vitreous Centre, Strathfield, New South Wales, Australia.
  • Lim LA; School of Medical Sciences, University of New South Wales, Sydney, Australia.
  • Grigg JR; Crows Nest Eye Surgery, Crows Nest, New South Wales, Australia.
  • Lin ML; Sydney Eye Hospital, Sydney, New South Wales, Australia.
  • Karaconji T; Sydney Eye Hospital, Sydney, New South Wales, Australia.
  • Giblin M; Save Sight Institute, Faculty of Medicine and Health, Sydney University, Sydney, New South Wales, Australia.
  • Symons A; Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.
  • Lim LL; Sydney Eye Hospital, Sydney, New South Wales, Australia.
  • McCluskey PJ; Sydney Eye Hospital, Sydney, New South Wales, Australia.
Retin Cases Brief Rep ; 15(6): 718-723, 2021 Nov 01.
Article in En | MEDLINE | ID: mdl-31274846
ABSTRACT
BACKGROUND/

PURPOSE:

To report the largest case series to date of uveitis occurring in association with immunomodulatory therapy for malignant melanoma.

METHODS:

A retrospective multicenter case review. Twenty-two patients with uveitis occurring in association with either immunotherapy or targeted immune therapy for malignant melanoma were identified.

RESULTS:

Of 22 patients, 11 had anterior uveitis in isolation. The remainder showed a variety of clinical features including panuveitis, ocular hypotony, papillitis, cystoid macular edema, and melanoma-associated retinopathy. Most patients responded well to treatment.

CONCLUSION:

We report the largest case series to date of patients with uveitis secondary to drug treatment for malignant melanoma. These cases are likely to increase in number in the future as newer immunomodulatory therapies for cancers are developed and the indications for these drugs increase. A dilemma arises when patients respond well to these drugs but develop vision-threatening side effects.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uveitis / Immunotherapy / Melanoma Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Retin Cases Brief Rep Year: 2021 Document type: Article Affiliation country: Australia
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uveitis / Immunotherapy / Melanoma Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Retin Cases Brief Rep Year: 2021 Document type: Article Affiliation country: Australia