Emerging Approaches for Ocular Surface Regeneration.
Curr Ophthalmol Rep
; 7(1): 1-10, 2019 Mar.
Article
in En
| MEDLINE
| ID: mdl-31275736
ABSTRACT
PURPOSE OF REVIEW In this manuscript, the recent advancements and novel approaches for regeneration of the ocular surface are summarized. RECENT FINDINGS:
Following severe injuries, persistent inflammation can alter the rehabilitative capability of the ocular surface environment. Limbal stem cell deficiency (LSCD) is one of the most characterized ocular surface disorders mediated by deficiency and/or dysfunction of the limbal epithelial stem cells (LESCs) located in the limbal niche. Currently, the most advanced approach for revitalizing the ocular surface and limbal niche is based on transplantation of limbal tissues harboring LESCs. Emerging approaches have focused on restoring the ocular surface microenvironment using (1) cell-based therapies including cells with capabilities to support the LESCs and modulate the inflammation, e.g., mesenchymal stem cells (MSCs), (2) bio-active extracellular matrices from decellularized tissues, and/or purified/synthetic molecules to regenerate the microenvironment structure, and (3) soluble cytokine/growth factor cocktails to revive the signaling pathways.SUMMARY:
Ocular surface/limbal environment revitalization provide promising approaches for regeneration of the ocular surface.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Curr Ophthalmol Rep
Year:
2019
Document type:
Article
Affiliation country:
Estados Unidos