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Molecular Computations of Preferential Interaction Coefficients of IgG1 Monoclonal Antibodies with Sorbitol, Sucrose, and Trehalose and the Impact of These Excipients on Aggregation and Viscosity.
Cloutier, Theresa; Sudrik, Chaitanya; Mody, Neil; Sathish, Hasige A; Trout, Bernhardt L.
Affiliation
  • Cloutier T; Chemical Engineering , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.
  • Sudrik C; Chemical Engineering , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.
  • Mody N; Dosage Form Design and Development, AstraZeneca , Gaithersburg , Maryland 20878 , United States.
  • Sathish HA; Dosage Form Design and Development, AstraZeneca , Gaithersburg , Maryland 20878 , United States.
  • Trout BL; Chemical Engineering , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.
Mol Pharm ; 16(8): 3657-3664, 2019 08 05.
Article in En | MEDLINE | ID: mdl-31276620
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Excipients / Molecular Dynamics Simulation / Antibodies, Monoclonal Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2019 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Excipients / Molecular Dynamics Simulation / Antibodies, Monoclonal Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2019 Document type: Article Affiliation country: Estados Unidos