Total Synthesis of the Marine Ladder Polyether Gymnocin B.
J Am Chem Soc
; 141(28): 11239-11244, 2019 07 17.
Article
in En
| MEDLINE
| ID: mdl-31283211
ABSTRACT
Herein, we report the first total synthesis of marine ladder polyether gymnocin B (1) based on a two-phase strategy. In Phase I, inspired by the proposed biosynthesis, epoxide-opening cascades assemble 10 out of 15 cyclic ether rings making up the molecular core. In the subsequent Phase II, coalescence elevates the molecular complexity further by coupling of these subunits. Our two-phase synthetic approach significantly improved the step efficiency of the synthesis of this class of natural products.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biological Products
/
Ethers, Cyclic
Language:
En
Journal:
J Am Chem Soc
Year:
2019
Document type:
Article
Affiliation country:
Estados Unidos