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Anti-signal Recognition Particle Antibody-positive Necrotizing Myopathy with Secondary Cardiomyopathy: The First Myocardial Biopsy- and Multimodal Imaging-proven Case.
Takeguchi-Kikuchi, Shiori; Hayasaka, Taiki; Katayama, Takayuki; Kano, Kohei; Takahashi, Kae; Saito, Tsukasa; Sawada, Jun; Minoshima, Akiho; Sakamoto, Naka; Akasaka, Kazumi; Miyokawa, Naoyuki; Nishino, Ichizo; Ishibashi-Ueda, Hatsue; Hasebe, Naoyuki.
Affiliation
  • Takeguchi-Kikuchi S; Division of Neurology, First Department of Internal Medicine, Asahikawa Medical University, Japan.
  • Hayasaka T; Division of Cardiology, First Department of Internal Medicine, Asahikawa Medical University, Japan.
  • Katayama T; Division of Neurology, First Department of Internal Medicine, Asahikawa Medical University, Japan.
  • Kano K; Division of Neurology, First Department of Internal Medicine, Asahikawa Medical University, Japan.
  • Takahashi K; Division of Neurology, First Department of Internal Medicine, Asahikawa Medical University, Japan.
  • Saito T; Division of Neurology, First Department of Internal Medicine, Asahikawa Medical University, Japan.
  • Sawada J; Division of Neurology, First Department of Internal Medicine, Asahikawa Medical University, Japan.
  • Minoshima A; Division of Cardiology, First Department of Internal Medicine, Asahikawa Medical University, Japan.
  • Sakamoto N; Division of Cardiology, First Department of Internal Medicine, Asahikawa Medical University, Japan.
  • Akasaka K; Division of Cardiology, First Department of Internal Medicine, Asahikawa Medical University, Japan.
  • Miyokawa N; Department of Clinical Pathology, Asahikawa Medical University, Japan.
  • Nishino I; Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan.
  • Ishibashi-Ueda H; Department of Pathology, National Cerebral and Cardiovascular Center, Japan.
  • Hasebe N; Division of Neurology, First Department of Internal Medicine, Asahikawa Medical University, Japan.
Intern Med ; 58(21): 3189-3194, 2019 Nov 01.
Article in En | MEDLINE | ID: mdl-31292376
ABSTRACT
A 69-year-old Japanese woman was admitted to our hospital with progressive muscle weakness and dysphagia. She was taking pitavastatin for dyslipidemia. Her serum creatine kinase was 6,300 U/L. Pitavastatin was stopped, but her symptoms deteriorated, and cardiac congestion appeared. A muscle biopsy showed necrotizing myopathy (NM), and anti-signal recognition particle (SRP) antibody was positive. 18F-fluorodeoxyglucose-positron emission tomography showed an abnormal uptake, and magnetic resonance imaging showed abnormal gadolinium enhancement in the left ventricular wall. An endomyocardial biopsy revealed inflammatory cardiomyopathy. Steroid, tacrolimus, and intravenous immunoglobulins were effective against the symptoms. This is the first case of biopsy-proven secondary cardiomyopathy due to anti-SRP-positive NM.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscle, Skeletal / Multimodal Imaging / Muscular Diseases / Cardiomyopathies Limits: Aged / Female / Humans Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2019 Document type: Article Affiliation country: Japón
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscle, Skeletal / Multimodal Imaging / Muscular Diseases / Cardiomyopathies Limits: Aged / Female / Humans Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2019 Document type: Article Affiliation country: Japón