Comparison of the effects of two different marine-derived omega-3 fatty acid sources, krill oil, and fish oil, on the healing of primary colonic anastomoses after colectomy applied Wistar albino rat model.
Ulus Travma Acil Cerrahi Derg
; 25(4): 324-330, 2019 Jul.
Article
in En
| MEDLINE
| ID: mdl-31297772
ABSTRACT
BACKGROUND:
Oils from marine organisms have a different fatty acid composition. Fish oil (FO) has a high content of eicosapentaenoic and docosahexaenoic acids esterified to triacylglycerols; while in krill oil (KO), fatty acids are primarily esterified to phospholipids. This study aimed to compare the efficacy of two different, marine-derived omega-3 fatty acid sources in the wound healing of colon anastomoses rat model.METHODS:
For the study, we used 42 male Wistar albino rats. The rats were divided into six groups with seven rats in each group-CO3 left colonic anastomosis (control group), sacrificed on the third day; KO3 left colonic anastomosis + oral KO, sacrificed on the third day; FO3 left colonic anastomosis + oral FO, sacrificed on the third day; CO7 left colonic anastomosis (control group), sacrificed on the seventh day; KO7 left colonic anastomosis + oral KO, sacrificed on the seventh day; FO7 left colonic anastomosis + oral FO, sacrificed on the seventh day. Peritoneal adhesions, anastomotic bursting pressures, hydroxyproline levels, and histological examination of the anastomotic tissue were evaluated.RESULTS:
On day 7, bursting pressure and hydroxyproline measurements of the KO group was significantly higher than the FO group (p=0.012; p=0.002, respectively). Also, on day 7, a statistically significant difference was observed between the groups according to inflammatory cell infiltration, fibroblast activity, neoangiogenesis, and collagen deposition in favor of the KO group (p=0.023; p=0.028; p=0.016; p=0.012, respectively).CONCLUSION:
Both KO and FO supplementation in patients before colorectal surgery may reduce some risk of anastomotic leakage; and KO might be a better alternative and excellent omega-3 source.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Wound Healing
/
Fish Oils
/
Fatty Acids, Omega-3
/
Colon
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Euphausiacea
Type of study:
Clinical_trials
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Ulus Travma Acil Cerrahi Derg
Year:
2019
Document type:
Article