APOE É4 Carriers Show Delayed Recovery of Verbal Memory and Smaller Entorhinal Volume in the First Year After Ischemic Stroke.
J Alzheimers Dis
; 71(1): 245-259, 2019.
Article
in En
| MEDLINE
| ID: mdl-31381519
ABSTRACT
BACKGROUND:
The apolipoprotein E (APOE) gene É4 allele is a risk factor for Alzheimer's disease and cardiovascular disease. However, its relationship with cognition and brain volume after stroke is not clear.OBJECTIVE:
We compared cognition and medial temporal lobe volumes in APOEÉ4 carriers and non-carriers in the first year after ischemic stroke.METHODS:
We sampled 20 APOEÉ4 carriers and 20 non-carriers from a larger cohort of 135 ischemic stroke participants in the longitudinal CANVAS study. Participants were matched on a range of demographic and stroke characteristics. We used linear mixed-effect models to compare cognitive domain z-scores (attention, processing speed, executive function, verbal and visual memory, language, visuospatial function) and regional medial temporal lobe volumes (hippocampal, entorhinal cortex) between groups at each time-point (3, 12-months post-stroke), and within groups across time-points. APOE gene single nucleotide polymorphisms (SNPs; rs7412, rs429358) were genotyped on venous blood.RESULTS:
APOEÉ4 carriers and non-carriers did not differ on any demographic, clinical, or stroke variable. Carriers performed worse than non-carriers in verbal memory at 3 months post-stroke (pâ=â0.046), but were better in executive function at 12 months (pâ=â0.035). Carriers demonstrated a significant improvement in verbal memory (pâ=â0.012) and executive function (pâ=â0.015) between time-points. Non-carriers demonstrated a significant improvement in visual memory (pâ=â0.0005). Carriers had smaller bilateral entorhinal cortex volumes (pâ<â0.05), and larger right sided and contralesional hippocampal volumes, at both time-points (pâ<â0.05).CONCLUSION:
APOE É4 is associated with delayed recovery of verbal memory function and reduced entorhinal cortex volumes in the first year after ischemic stroke.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Verbal Learning
/
Brain Ischemia
/
Entorhinal Cortex
/
Stroke
/
Apolipoprotein E4
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Alzheimers Dis
Journal subject:
GERIATRIA
/
NEUROLOGIA
Year:
2019
Document type:
Article
Affiliation country:
Australia