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Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans.
Weisová, Petronela; Cehlár, Ondrej; Skrabana, Rostislav; Zilková, Monika; Filipcík, Peter; Kovácech, Branislav; Prcina, Michal; Wojciaková, Lubica; Fialová, Lubica; Smolek, Tomás; Kontseková, Eva; Zilka, Norbert; Novák, Michal.
Affiliation
  • Weisová P; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic. weisova@axon-neuroscience.eu.
  • Cehlár O; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
  • Skrabana R; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
  • Zilková M; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
  • Filipcík P; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
  • Kovácech B; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
  • Prcina M; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
  • Wojciaková L; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
  • Fialová L; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
  • Smolek T; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
  • Kontseková E; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
  • Zilka N; Department of Neuroimmunology, Axon Neuroscience R&D Services SE, Dvorákovo nábrezie 10, Bratislava, Slovak Republic.
  • Novák M; Axon Neuroscience SE, Arch. Makariou & Kalogreon 4, Larnaca, Cyprus.
Acta Neuropathol Commun ; 7(1): 129, 2019 08 07.
Article in En | MEDLINE | ID: mdl-31391090
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteoglycans / Tau Proteins / Microtubules / Antibodies, Monoclonal / Neurons Limits: Animals / Female / Humans / Pregnancy Language: En Journal: Acta Neuropathol Commun Year: 2019 Document type: Article Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteoglycans / Tau Proteins / Microtubules / Antibodies, Monoclonal / Neurons Limits: Animals / Female / Humans / Pregnancy Language: En Journal: Acta Neuropathol Commun Year: 2019 Document type: Article Country of publication: Reino Unido