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Interspecies Organogenesis for Human Transplantation.
Crane, Andrew T; Aravalli, Rajagopal N; Asakura, Atsushi; Grande, Andrew W; Krishna, Venkatramana D; Carlson, Daniel F; Cheeran, Maxim C-J; Danczyk, Georgette; Dutton, James R; Hackett, Perry B; Hu, Wei-Shou; Li, Ling; Lu, Wei-Cheng; Miller, Zachary D; O'Brien, Timothy D; Panoskaltsis-Mortari, Angela; Parr, Ann M; Pearce, Clairice; Ruiz-Estevez, Mercedes; Shiao, Maple; Sipe, Christopher J; Toman, Nikolas G; Voth, Joseph; Xie, Hui; Steer, Clifford J; Low, Walter C.
Affiliation
  • Crane AT; Department of Neurosurgery, University of Minnesota, Minneapolis, USA.
  • Aravalli RN; Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, USA.
  • Asakura A; Stem Cell Institute, University of Minnesota, Minneapolis, USA.
  • Grande AW; Department of Neurology, University of Minnesota, Minneapolis, USA.
  • Krishna VD; Department of Neurosurgery, University of Minnesota, Minneapolis, USA.
  • Carlson DF; Department of Veterinary Population Medicine, University of Minnesota, St. Paul, USA.
  • Cheeran MC; Recombinetics, Inc., St. Paul, USA.
  • Danczyk G; Department of Veterinary Population Medicine, University of Minnesota, St. Paul, USA.
  • Dutton JR; Department of Neurosurgery, University of Minnesota, Minneapolis, USA.
  • Hackett PB; Stem Cell Institute, University of Minnesota, Minneapolis, USA.
  • Hu WS; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, USA.
  • Li L; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, USA.
  • Lu WC; Department of Chemical Engineering and Material Science, University of Minnesota, Minneapolis, USA.
  • Miller ZD; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, USA.
  • O'Brien TD; Department of Neurosurgery, University of Minnesota, Minneapolis, USA.
  • Panoskaltsis-Mortari A; Department of Neurosurgery, University of Minnesota, Minneapolis, USA.
  • Parr AM; Stem Cell Institute, University of Minnesota, Minneapolis, USA.
  • Pearce C; Department of Veterinary Population Medicine, University of Minnesota, St. Paul, USA.
  • Ruiz-Estevez M; Department of Pediatrics, University of Minnesota, Minneapolis, USA.
  • Shiao M; Department of Neurosurgery, University of Minnesota, Minneapolis, USA.
  • Sipe CJ; Stem Cell Institute, University of Minnesota, Minneapolis, USA.
  • Toman NG; Department of Neurosurgery, University of Minnesota, Minneapolis, USA.
  • Voth J; Department of Neurosurgery, University of Minnesota, Minneapolis, USA.
  • Xie H; Department of Neurosurgery, University of Minnesota, Minneapolis, USA.
  • Steer CJ; Department of Neurosurgery, University of Minnesota, Minneapolis, USA.
  • Low WC; Department of Neurosurgery, University of Minnesota, Minneapolis, USA.
Cell Transplant ; 28(9-10): 1091-1105, 2019.
Article in En | MEDLINE | ID: mdl-31426664
ABSTRACT
Blastocyst complementation combined with gene editing is an emerging approach in the field of regenerative medicine that could potentially solve the worldwide problem of organ shortages for transplantation. In theory, blastocyst complementation can generate fully functional human organs or tissues, grown within genetically engineered livestock animals. Targeted deletion of a specific gene(s) using gene editing to cause deficiencies in organ development can open a niche for human stem cells to occupy, thus generating human tissues. Within this review, we will focus on the pancreas, liver, heart, kidney, lung, and skeletal muscle, as well as cells of the immune and nervous systems. Within each of these organ systems, we identify and discuss (i) the common causes of organ failure; (ii) the current state of regenerative therapies; and (iii) the candidate genes to knockout and enable specific exogenous organ development via the use of blastocyst complementation. We also highlight some of the current barriers limiting the success of blastocyst complementation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blastocyst / Animals, Genetically Modified / Organ Transplantation / Gene Expression Regulation, Developmental / Pluripotent Stem Cells / Organogenesis Limits: Animals / Humans Language: En Journal: Cell Transplant Journal subject: TRANSPLANTE Year: 2019 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blastocyst / Animals, Genetically Modified / Organ Transplantation / Gene Expression Regulation, Developmental / Pluripotent Stem Cells / Organogenesis Limits: Animals / Humans Language: En Journal: Cell Transplant Journal subject: TRANSPLANTE Year: 2019 Document type: Article Affiliation country: Estados Unidos