Structural, functional, and neurochemical neuroimaging of methamphetamine-associated psychosis: A systematic review.
Psychiatry Res Neuroimaging
; 292: 23-31, 2019 10 30.
Article
in En
| MEDLINE
| ID: mdl-31476712
ABSTRACT
Methamphetamine is a highly addictive psychostimulant. A subset of methamphetamine users develops methamphetamine-associated psychosis (MAP), which causes poorer prognoses and cognitive function than those with no psychosis (MNP). Comprehensive and integrative summaries of studies utilizing various neuroimaging modalities (structural, functional, and neurochemical) are limited. We conducted a systematic review of literature regarding clinical neuroimaging research published between January 1988 and July 2018 using the PubMed, Web of Science, Scopus, and ScienceDirect databases. Studies comparing the neuroimaging of patients with MAP with healthy controls or patients with MNP or schizophrenia were included to understand the distinct profiles associated with MAP. A total of six structural, three functional, and three neurochemical studies were reviewed. A general trend was identified that showed MAP-related brain alterations were mainly in the frontal lobe (especially the orbitofrontal cortex), striatum, and limbic systems (amygdala and hippocampus). Furthermore, some clinical manifestations, such as the severity of psychotic symptoms and cognitive performance, were correlated with neuroimaging abnormalities. In summary, distinct structural, functional, and neurochemical changes, especially in the frontostriatal circuit and network dynamic systems, play critical roles in the pathophysiology of MAP. Future studies using longitudinal study designs and including individuals with MNP and schizophrenia as controls are warranted.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Psychoses, Substance-Induced
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Brain
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Neuroimaging
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Central Nervous System Stimulants
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Methamphetamine
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Nerve Net
Type of study:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
/
Systematic_reviews
Limits:
Adult
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Psychiatry Res Neuroimaging
Year:
2019
Document type:
Article
Affiliation country:
Taiwán