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A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein.
Tang, Aimin; Chen, Zhifeng; Cox, Kara S; Su, Hua-Poo; Callahan, Cheryl; Fridman, Arthur; Zhang, Lan; Patel, Sangita B; Cejas, Pedro J; Swoyer, Ryan; Touch, Sinoeun; Citron, Michael P; Govindarajan, Dhanasekaran; Luo, Bin; Eddins, Michael; Reid, John C; Soisson, Stephen M; Galli, Jennifer; Wang, Dai; Wen, Zhiyun; Heidecker, Gwendolyn J; Casimiro, Danilo R; DiStefano, Daniel J; Vora, Kalpit A.
Affiliation
  • Tang A; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA.
  • Chen Z; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA.
  • Cox KS; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA.
  • Su HP; Department of Structural Chemistry and Chemical Biotechnology, Merck & Co., Inc, West Point, PA, USA.
  • Callahan C; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA.
  • Fridman A; Department of Scientific Informatics, Merck & Co., Inc., Rahway, NJ, USA.
  • Zhang L; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA.
  • Patel SB; Department of Structural Chemistry and Chemical Biotechnology, Merck & Co., Inc, West Point, PA, USA.
  • Cejas PJ; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA.
  • Swoyer R; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA.
  • Touch S; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA.
  • Citron MP; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA.
  • Govindarajan D; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA.
  • Luo B; Janssen Research & Development, 1400 McKean Road, Ambler, PA, 19002, USA.
  • Eddins M; Department of Pharmacology, Merck & Co., Inc., West Point, PA, USA.
  • Reid JC; Department of Structural Chemistry and Chemical Biotechnology, Merck & Co., Inc, West Point, PA, USA.
  • Soisson SM; Department of Structural Chemistry and Chemical Biotechnology, Merck & Co., Inc, West Point, PA, USA.
  • Galli J; Department of Structural Chemistry and Chemical Biotechnology, Merck & Co., Inc, West Point, PA, USA.
  • Wang D; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA.
  • Wen Z; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA.
  • Heidecker GJ; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA.
  • Casimiro DR; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA.
  • DiStefano DJ; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA.
  • Vora KA; Sanofi Pasteur, 1 Discovery Drive, Swiftwater, PA, 18370, USA.
Nat Commun ; 10(1): 4153, 2019 09 12.
Article in En | MEDLINE | ID: mdl-31515478
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glycoproteins / Viral Fusion Proteins / Conserved Sequence / Respiratory Syncytial Virus, Human / Broadly Neutralizing Antibodies / Antibodies, Viral Limits: Animals / Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country: Estados Unidos
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glycoproteins / Viral Fusion Proteins / Conserved Sequence / Respiratory Syncytial Virus, Human / Broadly Neutralizing Antibodies / Antibodies, Viral Limits: Animals / Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country: Estados Unidos