Role of intrinsic disorder in muscle sarcomeres.
Prog Mol Biol Transl Sci
; 166: 311-340, 2019.
Article
in En
| MEDLINE
| ID: mdl-31521234
ABSTRACT
The role and utility of intrinsically disordered regions (IDRs) is reviewed for two groups of sarcomeric proteins, such as members of tropomodulin/leiomodin (Tmod/Lmod) protein homology group and myosin binding protein C (MyBP-C). These two types of sarcomeric proteins represent very different but strongly interdependent functions, being responsible for maintaining structure and operation of the muscle sarcomere. The role of IDRs in the formation of complexes between thin filaments and Tmods/Lmods is discussed within the framework of current understanding of the thin filament length regulation. For MyBP-C, the function of IDRs is discussed in the context of MYBP-C-dependent sarcomere contraction and actomyosin activation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sarcomeres
/
Tropomodulin
/
Intrinsically Disordered Proteins
/
Muscles
Limits:
Animals
/
Humans
Language:
En
Journal:
Prog Mol Biol Transl Sci
Journal subject:
BIOLOGIA MOLECULAR
Year:
2019
Document type:
Article