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Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases.
Akoumianakis, Ioannis; Sanna, Fabio; Margaritis, Marios; Badi, Ileana; Akawi, Nadia; Herdman, Laura; Coutinho, Patricia; Fagan, Harry; Antonopoulos, Alexios S; Oikonomou, Evangelos K; Thomas, Sheena; Chiu, Amy P; Chuaiphichai, Surawee; Kotanidis, Christos P; Christodoulides, Constantinos; Petrou, Mario; Krasopoulos, George; Sayeed, Rana; Lv, Lei; Hale, Ashley; Naeimi Kararoudi, Meisam; McNeill, Eileen; Douglas, Gillian; George, Sarah; Tousoulis, Dimitris; Channon, Keith M; Antoniades, Charalambos.
Affiliation
  • Akoumianakis I; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Sanna F; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Margaritis M; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Badi I; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Akawi N; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Herdman L; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Coutinho P; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Fagan H; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Antonopoulos AS; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Oikonomou EK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Thomas S; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Chiu AP; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Chuaiphichai S; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Kotanidis CP; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Christodoulides C; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.
  • Petrou M; Department of Cardiothoracic Surgery, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, UK.
  • Krasopoulos G; Department of Cardiothoracic Surgery, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, UK.
  • Sayeed R; Department of Cardiothoracic Surgery, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, UK.
  • Lv L; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Hale A; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Naeimi Kararoudi M; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • McNeill E; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Douglas G; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • George S; Bristol Medical School, University of Bristol, Research Floor Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK.
  • Tousoulis D; Cardiology Department, Athens University Medical School, Athens 115 27, Greece.
  • Channon KM; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
  • Antoniades C; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK. antoniad@well.ox.ac.uk.
Sci Transl Med ; 11(510)2019 09 18.
Article in En | MEDLINE | ID: mdl-31534019
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endopeptidases / Blood Vessels / Signal Transduction / Adipose Tissue / NADPH Oxidases / Rac1 GTP-Binding Protein / Wnt-5a Protein / Obesity Limits: Animals Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2019 Document type: Article Affiliation country: Reino Unido Country of publication: Estados Unidos
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Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endopeptidases / Blood Vessels / Signal Transduction / Adipose Tissue / NADPH Oxidases / Rac1 GTP-Binding Protein / Wnt-5a Protein / Obesity Limits: Animals Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2019 Document type: Article Affiliation country: Reino Unido Country of publication: Estados Unidos