Predictors of relapse in patients with medication overuse headache in Shanghai: A retrospective study with a 6-month follow-up.
J Clin Neurosci
; 70: 33-36, 2019 Dec.
Article
in En
| MEDLINE
| ID: mdl-31540858
ABSTRACT
Medication overuse headache (MOH) has a high relapse rate and disease heterogeneity. This study aimed to determine the predictors of MOH relapse in patients through a 6-month follow-up in Shanghai. In this retrospective study, patients diagnosed with MOH from June 2016 to June 2017 were recruited and followed up for 6â¯months after withdrawal treatment in Renji Hospital in Shanghai. Patients' information was obtained using headache questionnaires. Follow-up was conducted via telephone interview. Patients were divided into relapse group and no-relapse group according to the outcomes after 6â¯months. This study enrolled 124 outpatients with MOH at baseline. 102 patients completed the follow up and were analysis finally. Demographics and clinical characteristics were compared between the relapse (nâ¯=â¯39, 38.24%) and no-relapse (nâ¯=â¯63, 61.76%) group. Binary logistic regression analysis was performed, and two variables emerged as significant predictors of relapse before withdrawal; the headache frequency (day/month) was higher in the relapse group than in the no-relapse group [odds ratio (OR) 1.107, pâ¯=â¯0.008]. Furthermore, patients administered analgesics ofâ¯≥â¯2 units per headache day had a higher risk of relapse [odds ratio (OR) 2.791, pâ¯=â¯0.038]. Headache frequency and analgesics units per headache day before withdrawal may be independent predictors of MOH relapse. Therefore, early identification of high-risk groups and enhancing patients' management could contribute to improving the prognosis of MOH.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Headache Disorders, Secondary
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
J Clin Neurosci
Journal subject:
NEUROLOGIA
Year:
2019
Document type:
Article
Affiliation country:
China