The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach.

Antonescu, Irina E; Rasmussen, Karina F; Neuhoff, Sibylle; Fretté, Xavier; Karlgren, Maria; Bergström, Christel A S; Nielsen, Carsten Uhd; Steffansen, Bente

Antonescu, Irina E; Rasmussen, Karina F; Neuhoff, Sibylle; Fretté, Xavier; Karlgren, Maria; Bergström, Christel A S; Nielsen, Carsten Uhd; Steffansen, Bente.

Affiliation

Rasmussen KF; Department of Pharmacy , University of Copenhagen , 2100 Copenhagen , Denmark.
Neuhoff S; Simcyp Division , Certara UK Ltd. , S1 2BJ Sheffield , U.K.
Karlgren M; Department of Pharmacy , Uppsala University , P.O. Box 580, SE-751 23 Uppsala , Sweden.
Bergström CAS; Department of Pharmacy , Uppsala University , P.O. Box 580, SE-751 23 Uppsala , Sweden.

Mol Pharm ; 16(11): 4636-4650, 2019 11 04.

Article in En | MEDLINE | ID: mdl-31560549

Subject(s)
Key words

Caco-2; acamprosate; paracellular modeling; paracellular permeability; permeability modeling; permeability-limited absorption; transcellular permeability

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acamprosate Limits: Humans Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2019 Document type: Article Country of publication: Estados Unidos

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