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PKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes.
Siddique, Salman Mahmud; Kubouchi, Koji; Shinmichi, Yuka; Sawada, Nana; Sugiura, Reiko; Itoh, Yasushi; Uehara, Shunsuke; Nishimura, Kanae; Okamura, Shunsuke; Ohsaki, Hiroyuki; Kamoshida, Shingo; Yamashita, Yusuke; Tamura, Shinobu; Sonoki, Takashi; Matsuoka, Hiroshi; Itoh, Tomoo; Mukai, Hideyuki.
Affiliation
  • Siddique SM; Graduate School of Medicine, Kobe University, Kobe, 650-0017, Japan.
  • Kubouchi K; Graduate School of Medicine, Kobe University, Kobe, 650-0017, Japan.
  • Shinmichi Y; Laboratory of Molecular Pharmacogenomics, School of Pharmaceutical Sciences, Kindai University, 3-4-1, Kowakae, Higashi-Osaka, 577- 8502, Japan.
  • Sawada N; Laboratory of Molecular Pharmacogenomics, School of Pharmaceutical Sciences, Kindai University, 3-4-1, Kowakae, Higashi-Osaka, 577- 8502, Japan.
  • Sugiura R; Laboratory of Molecular Pharmacogenomics, School of Pharmaceutical Sciences, Kindai University, 3-4-1, Kowakae, Higashi-Osaka, 577- 8502, Japan.
  • Itoh Y; Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan.
  • Uehara S; Department of Biochemistry, Matsumoto Dental University, Shiojiri, Nagano, 399-0781, Japan.
  • Nishimura K; Laboratory of Pathology, Department of Medical Biophysics, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma, Kobe, Hyogo, 654-0142, Japan.
  • Okamura S; Laboratory of Pathology, Department of Medical Biophysics, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma, Kobe, Hyogo, 654-0142, Japan.
  • Ohsaki H; Laboratory of Pathology, Department of Medical Biophysics, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma, Kobe, Hyogo, 654-0142, Japan.
  • Kamoshida S; Laboratory of Pathology, Department of Medical Biophysics, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma, Kobe, Hyogo, 654-0142, Japan.
  • Yamashita Y; Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
  • Tamura S; Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
  • Sonoki T; Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
  • Matsuoka H; Division of Medical Oncology and Hematology, Kobe University Hospital, Kobe, Hyogo, Japan.
  • Itoh T; Department of Diagnostic Pathology, Kobe University Hospital, Kobe, Hyogo, 650-0017, Japan.
  • Mukai H; Graduate School of Medicine, Kobe University, Kobe, 650-0017, Japan. mukinase@kobe-u.ac.jp.
Sci Rep ; 9(1): 13977, 2019 Sep 27.
Article in En | MEDLINE | ID: mdl-31562379
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Splenomegaly / Protein Kinase C / Leukopenia Limits: Animals Language: En Journal: Sci Rep Year: 2019 Document type: Article Affiliation country: Japón
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Splenomegaly / Protein Kinase C / Leukopenia Limits: Animals Language: En Journal: Sci Rep Year: 2019 Document type: Article Affiliation country: Japón