Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect.
Eur J Med Chem
; 183: 111736, 2019 Dec 01.
Article
in En
| MEDLINE
| ID: mdl-31586817
ABSTRACT
A series of novel 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives were synthesised and evaluated for their 5-HT1A/D2/5-HT2A/5-HT6/5-HT7 receptor affinity and serotonin reuptake inhibition. Most of the evaluated compounds displayed high affinities for 5-HT1A receptors (e.g., 4cKiâ¯=â¯2.3â¯nM, 4lKiâ¯=â¯3.2â¯nM). The antidepressant activity of the selected compounds was screened in vivo using the forced swim test (FST). The results indicate that compound MW005 (agonist of the pre- and postsynaptic 5-HT1A receptor) exhibited promising affinities for the 5-HT1A/SERT/D2/5-HT6/5-HT7 receptors and showed an antidepressant-like activity in the FST model.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrrolidinones
/
Indoles
/
Antidepressive Agents
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Eur J Med Chem
Year:
2019
Document type:
Article