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Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer.
Joshi, Kroopa; de Massy, Marc Robert; Ismail, Mazlina; Reading, James L; Uddin, Imran; Woolston, Annemarie; Hatipoglu, Emine; Oakes, Theres; Rosenthal, Rachel; Peacock, Thomas; Ronel, Tahel; Noursadeghi, Mahdad; Turati, Virginia; Furness, Andrew J S; Georgiou, Andrew; Wong, Yien Ning Sophia; Ben Aissa, Assma; Sunderland, Mariana Werner; Jamal-Hanjani, Mariam; Veeriah, Selvaraju; Birkbak, Nicolai J; Wilson, Gareth A; Hiley, Crispin T; Ghorani, Ehsan; Guerra-Assunção, José Afonso; Herrero, Javier; Enver, Tariq; Hadrup, Sine R; Hackshaw, Allan; Peggs, Karl S; McGranahan, Nicholas; Swanton, Charles; Quezada, Sergio A; Chain, Benny.
Affiliation
  • Joshi K; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.
  • de Massy MR; Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, London, UK.
  • Ismail M; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.
  • Reading JL; Division of Infection and Immunity, University College London, London, UK.
  • Uddin I; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.
  • Woolston A; Division of Infection and Immunity, University College London, London, UK.
  • Hatipoglu E; Division of Infection and Immunity, University College London, London, UK.
  • Oakes T; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.
  • Rosenthal R; Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, London, UK.
  • Peacock T; Division of Infection and Immunity, University College London, London, UK.
  • Ronel T; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
  • Noursadeghi M; Bill Lyons Informatics Centre, University College London Cancer Institute, London, UK.
  • Turati V; Division of Infection and Immunity, University College London, London, UK.
  • Furness AJS; Computation, Mathematics and Physics in the Life Sciences and Experimental Biology, Department of Computer Science, University College London, London, UK.
  • Georgiou A; Division of Infection and Immunity, University College London, London, UK.
  • Wong YNS; Division of Infection and Immunity, University College London, London, UK.
  • Ben Aissa A; Department of Cancer Biology, University College London Cancer Institute, London, UK.
  • Sunderland MW; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.
  • Jamal-Hanjani M; Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, London, UK.
  • Veeriah S; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.
  • Birkbak NJ; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.
  • Wilson GA; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.
  • Hiley CT; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
  • Ghorani E; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.
  • Guerra-Assunção JA; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
  • Herrero J; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
  • Enver T; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
  • Hadrup SR; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
  • Hackshaw A; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
  • Peggs KS; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
  • McGranahan N; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK.
  • Swanton C; Bill Lyons Informatics Centre, University College London Cancer Institute, London, UK.
  • Quezada SA; University College London Cancer Institute, London, UK.
  • Chain B; Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.
Nat Med ; 25(10): 1549-1559, 2019 10.
Article in En | MEDLINE | ID: mdl-31591606
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Antigen, T-Cell / Immunotherapy, Adoptive / Carcinoma, Non-Small-Cell Lung / Genetic Heterogeneity Type of study: Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2019 Document type: Article Affiliation country: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Antigen, T-Cell / Immunotherapy, Adoptive / Carcinoma, Non-Small-Cell Lung / Genetic Heterogeneity Type of study: Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2019 Document type: Article Affiliation country: Reino Unido