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Comprehensive kinetic and modeling analyses revealed CYP2C9 and 3A4 determine terbinafine metabolic clearance and bioactivation.
Barnette, Dustyn A; Davis, Mary A; Flynn, Noah; Pidugu, Anirudh S; Swamidass, S Joshua; Miller, Grover P.
Affiliation
  • Barnette DA; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
  • Davis MA; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.
  • Flynn N; Department of Pathology and Immunology, Washington University, St. Louis, MO 63130, United States.
  • Pidugu AS; Department of Chemistry, Emory University, Atlanta, GA 30322, Georgia.
  • Swamidass SJ; Department of Pathology and Immunology, Washington University, St. Louis, MO 63130, United States.
  • Miller GP; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States. Electronic address: MillerGroverP@uams.edu.
Biochem Pharmacol ; 170: 113661, 2019 12.
Article in En | MEDLINE | ID: mdl-31605674
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microsomes, Liver / Cytochrome P-450 CYP3A / Cytochrome P-450 CYP2C9 / Terbinafine Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biochem Pharmacol Year: 2019 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microsomes, Liver / Cytochrome P-450 CYP3A / Cytochrome P-450 CYP2C9 / Terbinafine Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biochem Pharmacol Year: 2019 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido