Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations.
Cell
; 179(3): 589-603, 2019 10 17.
Article
in En
| MEDLINE
| ID: mdl-31607513
ABSTRACT
Genome-wide association studies (GWASs) have focused primarily on populations of European descent, but it is essential that diverse populations become better represented. Increasing diversity among study participants will advance our understanding of genetic architecture in all populations and ensure that genetic research is broadly applicable. To facilitate and promote research in multi-ancestry and admixed cohorts, we outline key methodological considerations and highlight opportunities, challenges, solutions, and areas in need of development. Despite the perception that analyzing genetic data from diverse populations is difficult, it is scientifically and ethically imperative, and there is an expanding analytical toolbox to do it well.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genome-Wide Association Study
/
Genotyping Techniques
/
Human Genetics
Type of study:
Risk_factors_studies
Aspects:
Ethics
Limits:
Humans
Language:
En
Journal:
Cell
Year:
2019
Document type:
Article