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Polymyxin derivatives as broad-spectrum antibiotic agents.
Su, Ma; Wang, Minghui; Hong, Yuzhu; Nimmagadda, Alekhya; Shen, Ning; Shi, Yan; Gao, Ruixuan; Zhang, En; Cao, Chuanhai; Cai, Jianfeng.
Affiliation
  • Su M; Department of Chemistry, University of South Florida, Tampa, FL 33620, USA. jianfengcai@usf.edu.
  • Wang M; Department of Chemistry, University of South Florida, Tampa, FL 33620, USA. jianfengcai@usf.edu.
  • Hong Y; College of Pharmacy, University of South Florida, Tampa, FL 33620, USA. ccao@health.usf.edu.
  • Nimmagadda A; Department of Chemistry, University of South Florida, Tampa, FL 33620, USA. jianfengcai@usf.edu.
  • Shen N; College of Pharmacy, University of South Florida, Tampa, FL 33620, USA. ccao@health.usf.edu.
  • Shi Y; Department of Chemistry, University of South Florida, Tampa, FL 33620, USA. jianfengcai@usf.edu.
  • Gao R; Department of Chemistry, University of South Florida, Tampa, FL 33620, USA. jianfengcai@usf.edu.
  • Zhang E; Department of Chemistry, University of South Florida, Tampa, FL 33620, USA. jianfengcai@usf.edu and School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, P. R. China.
  • Cao C; College of Pharmacy, University of South Florida, Tampa, FL 33620, USA. ccao@health.usf.edu.
  • Cai J; Department of Chemistry, University of South Florida, Tampa, FL 33620, USA. jianfengcai@usf.edu.
Chem Commun (Camb) ; 55(87): 13104-13107, 2019 Oct 29.
Article in En | MEDLINE | ID: mdl-31612170
ABSTRACT
We designed a few polymyxin derivatives which exhibit broad-spectrum antimicrobial activity. Lead compound P1 could disrupt bacterial membranes rapidly without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in an MRSA-infected thigh burden mouse model.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymyxins / Escherichia coli / Methicillin-Resistant Staphylococcus aureus / Anti-Bacterial Agents Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2019 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymyxins / Escherichia coli / Methicillin-Resistant Staphylococcus aureus / Anti-Bacterial Agents Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2019 Document type: Article Affiliation country: Estados Unidos