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Hippocampal CA1 Somatostatin Interneurons Originate in the Embryonic MGE/POA.
Asgarian, Zeinab; Magno, Lorenza; Ktena, Niki; Harris, Kenneth D; Kessaris, Nicoletta.
Affiliation
  • Asgarian Z; Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK; Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
  • Magno L; Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK; Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
  • Ktena N; Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.
  • Harris KD; UCL Institute of Neurology at the Cruciform Building and Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
  • Kessaris N; Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK; Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: n.kessaris@ucl.ac.uk.
Stem Cell Reports ; 13(5): 793-802, 2019 11 12.
Article in En | MEDLINE | ID: mdl-31631021
Oriens lacunosum-moleculare (O-LM) interneurons constitute 40% of hippocampal interneurons expressing Somatostatin (SST). Recent evidence has indicated a dual origin for these cells in the medial and caudal ganglionic eminences (MGE and CGE), with expression of Htr3a as a distinguishing factor. This is strikingly different from cortical SST interneurons that have a single origin within the MGE/preoptic area (POA). We reassessed the origin of hippocampal SST interneurons using a range of genetic lineage-tracing mice combined with single-cell transcriptomic analysis. We find a common origin for all hippocampal SST interneurons in NKX2-1-expressing progenitors of the telencephalic neuroepithelium and an MGE/POA-like transcriptomic signature for all SST clusters. This suggests that functional heterogeneity within the SST CA1 population cannot be attributed to a differential MGE/CGE genetic origin.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Somatostatin / CA1 Region, Hippocampal / Interneurons Limits: Animals Language: En Journal: Stem Cell Reports Year: 2019 Document type: Article Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Somatostatin / CA1 Region, Hippocampal / Interneurons Limits: Animals Language: En Journal: Stem Cell Reports Year: 2019 Document type: Article Country of publication: Estados Unidos