Coevolutionary Couplings Unravel PAM-Proximal Constraints of CRISPR-SpCas9.

Li, Yi; De la Paz, José A; Jiang, Xianli; Liu, Richard; Pokkulandra, Adarsha P; Bleris, Leonidas; Morcos, Faruck

Li, Yi; De la Paz, José A; Jiang, Xianli; Liu, Richard; Pokkulandra, Adarsha P; Bleris, Leonidas; Morcos, Faruck.

Affiliation

Li Y; Department of Bioengineering, The University of Texas at Dallas, Richardson, Texas; Center for Systems Biology, The University of Texas at Dallas, Richardson, Texas.
De la Paz JA; Department of Biological Sciences, The University of Texas at Dallas, Richardson, Texas.
Jiang X; Department of Biological Sciences, The University of Texas at Dallas, Richardson, Texas.
Liu R; Department of Bioengineering, The University of Texas at Dallas, Richardson, Texas.
Pokkulandra AP; School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, Texas.
Bleris L; Department of Bioengineering, The University of Texas at Dallas, Richardson, Texas; Center for Systems Biology, The University of Texas at Dallas, Richardson, Texas; Department of Biological Sciences, The University of Texas at Dallas, Richardson, Texas. Electronic address: bleris@utdallas.edu.
Morcos F; Department of Bioengineering, The University of Texas at Dallas, Richardson, Texas; Center for Systems Biology, The University of Texas at Dallas, Richardson, Texas; Department of Biological Sciences, The University of Texas at Dallas, Richardson, Texas. Electronic address: faruckm@utdallas.edu.

Biophys J ; 117(9): 1684-1691, 2019 11 05.

Article in En | MEDLINE | ID: mdl-31648792

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Evolution, Molecular / Nucleotide Motifs / CRISPR-Cas Systems / CRISPR-Associated Protein 9 Limits: Humans Language: En Journal: Biophys J Year: 2019 Document type: Article Country of publication: Estados Unidos

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