[Mouse Models of Sepsis and Septic Shock].
Mol Biol (Mosk)
; 53(5): 799-814, 2019.
Article
in Ru
| MEDLINE
| ID: mdl-31661479
ABSTRACT
An extensive network of regulation of systemic inflammation makes development of a reproducible experimental model of sepsis a complex task. There is no single mouse model that can capture all clinical aspects of this complicated pathology. However, a combination of existing approaches can go a long way towards analysis of specific mechanisms of sepsis development and to the design of novel therapeutic approaches. This review describes the popular mouse models of sepsis and septic shock, as well as their limitations and development strategies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Shock, Septic
/
Sepsis
/
Disease Models, Animal
Limits:
Animals
Language:
Ru
Journal:
Mol Biol (Mosk)
Year:
2019
Document type:
Article